Estrogen-enzyme interactions: Inhibition and protection of kynurenine transaminase by the sulfate esters of diethylstilbestrol, estradiol, and estrone.
نویسندگان
چکیده
In a preliminary report (I), we have described an intense inhibitory action of the sulfate esters of estrone, estradiol, and diethylstilbestrol on the kynurenine transaminase of rat kidney and on the phosphorylase a of rabbit muscle. More recently, we have also found that this interaction results in protection of the kynurenine transaminase from proteolysis and from the inactivation that normally accompanies incubation. The inhibition and protection of kynurenine transaminase by the estrogen sulfates are described in detail in this communication.
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ورودعنوان ژورنال:
- The Journal of biological chemistry
دوره 235 شماره
صفحات -
تاریخ انتشار 1960